![[Search]](/static/images/search.gif){kind=small}
![[A-Z Index]](/static/images/az.gif){kind=small}
![[Contact]](/static/images/contact.gif){kind=small}
![[University of Cambridge]](/static/images/identifier2.gif){kind=small}
![[Talks.cam]](/static/images/talkslogosmall.gif)
Anna Erzberger (EMBL Heidelberg, Germany) 
Monday 18 January 2021, 14:30-16:00
First a war then a dance: How sensory organs take shape
- 👤 Speaker: Anna Erzberger (EMBL Heidelberg, Germany) 🔗 Website
- 📅 Date & Time: Monday 18 January 2021, 14:30 - 16:00
- 📍 Venue: Online
Abstract
Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here, we investigate how an organ-level polarity pattern emerges through symmetry breaking at the cellular level during the formation of a mechanosensory organ. Combining theory, genetic perturbations and in vivo imaging, we study the development and regeneration of the fluid-motion sensors in the zebrafish’s lateral line. We find that two interacting symmetry-breaking events—one mediated by biochemical signalling and the other by cellular mechanics—give rise to precise rotations of cell pairs, which produce a mirror-symmetric polarity pattern in the receptor organ.
Series This talk is part of the Morphogenesis Seminar Series series.
Included in Lists
Note: Ex-directory lists are not shown.