Abstract

Bioelectronic probes are a crucial component of neuroprostheses, brain-machine interfaces and some organ-on-chip systems. Such devices have to seamlessly integrate with the host biological system, be anatomy adapted, soft and enabled for multi-modal information exchange. In this talk, I will present a strategy for rapid prototyping (3D printing) of bespoke neural implants and microphysiological platforms. It relies on well-established fabrication tools such as direct ink writing (extrusion) and inkjet printing and a palette of inorganic soft materials. Printed devices are deployed in several niches of the nervous system in vivo as well as for multi-modal interfacing of cell cultures. I will also discuss our efforts to engineer “electronic tissue” materials based on conductive polymers and hydrogels. These are designed to combine softness, electrical and biochemical properties that go beyond those of inorganic materials.