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Regulation of physiology via a dietary lipid metabolite.

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  • UserProfessor Aurelio Teleman, German Cancer Research Center (DKFZ), Heidelberg
  • ClockThursday 16 June 2022, 14:00-15:00
  • HouseZoom meeting.

If you have a question about this talk, please contact Caroline Newnham .

Host - Felipe Karam Teixeira

Metabolism and cell signaling are tightly interconnected, with each one regulating the other. The mechanisms how cell signaling regulates metabolic pathways have been extensively studied, for instance via transcriptional regulation of gene expression or via post-translational regulation of metabolic enzymes. I will discuss the other direction – how metabolites regulate signaling pathways. One mechanism is via formation of post-translational modifications of protein via metabolites. One example of such a reversible modification is S-acylation, the attachment of lipids to protein cysteines via thioester bonds. I will discuss recent evidence that different lipids compete for acylation of single sites on proteins, thereby regulating their function.

This talk is part of the Genetics Seminar series.

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In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom link https://mrc-lmb-cam-ac-uk.zoom.us/j/96372751903?pwd=C2hRQ8UF0B03vDp6IHGfWuTlsqzrTi.1 Goldsmith's 2 & https://us06web.zoom.us/j/81688365420?pwd=b3RpdHgxNVhWbWQrbXluMUxYNWVtQT09 Meeting ID: 816 8836 5420 Passcode: 047859 Room FW26, Computer Laboratory, William Gates Building.

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