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Functional redundancy of Drosophila melanogaster SoxB proteins in central nervous system development

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If you have a question about this talk, please contact Dr Tamsin Samuels .

Grab some lunch from the Darwin servery and enjoy an interesting science talk and discussion over lunch. First come first served up to 30 people capacity. Looking forward to seeing you there.

During neural development, SoxB proteins are transcriptions factors that play an important role in the maintenance of stem-cell identity. One member of this family, Sox2 has been successfully used to induce cells into a pluripotent state (iPSCs) and is involved in different disorders promoting cells self-renewal. Interestingly, SoxB proteins have shown pioneer and redundant activity even when natural selection imposes evolutionary pressure to prevent gene duplications. Moreover, a high functional conservation and high levels of sequence similarity, allow us to assess functionality in vivo and at a chromatin level using Drosophila melanogaster as our model organism and its genes SoxN and Dichaete, orthologs of mammalian and other vertebrates SoxB genes

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