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Wednesday 13 October 2021, 16:00-17:00
ApoE, Ab and Alzheimer’s disease: From test tube to transgenic mice
- 👤 Speaker: Mary Jo LaDu, University of Illinois at Chicago
- 📅 Date & Time: Wednesday 13 October 2021, 16:00 - 17:00
- 📍 Venue: https://zoom.us/j/92564124601
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Alyssa Miller
Abstract
Seminar Outline (Major concepts to be discussed):
Background:- Alzheimer’s disease (AD) is the most common cause of dementia. While rare, familial AD is caused by genetic mutations that increase the production of Ab42.
- Age, APOE genotype and sex are the universal biological variables (UBV) of AD risk.
- Biochemical detection
- In vitro function
- Biochemical assembly
- In vitro function
- Optimization of a 3-step sequential protein extraction
- Characterization of a new Ab-specific monoclonal antibody
- Development of oligomer-specific ELISA
- Generation of the EFAD transgenic mouse model
The EFAD transgenic mice develop AD-relevant pathology that increases significantly with age, APOE4 and female sex, mirroring human AD risk.
Series This talk is part of the Biophysical Seminars series.
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