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Noemie Lefrancq (University of Cambridge)
Wednesday 04 May 2022, 16:00-17:00
Estimating global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis using genetic data.
- đ¤ Speaker: Noemie Lefrancq (University of Cambridge)
- đ Date & Time: Wednesday 04 May 2022, 16:00 - 17:00
- đ Venue: Zoom
Abstract
Bordetella pertussis (Bp), which causes whooping cough, infects >24 million individuals annually despite widespread vaccination. Asymptomatic carriage and multiple circulating lineages hide the underlying dynamics of Bp from surveillance systems. Therefore, the extent of spread across spatial scales remains a mystery, as does the role of vaccines in driving changes in strain fitness. Models informed by pathogen sequences can help. In this seminar I will present how models informed by >3300 genomes shed light on Bp spatial structure, rate of geographic spread, and fitness shifts in response to vaccine changes. Link to the paper: https://www.science.org/doi/10.1126/scitranslmed.abn3253
Series This talk is part of the Worms and Bugs series.
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