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Regulatory T cells inhibit antigen-dependent T cell function but not bystander T cell activity: implications for pathogenesis of RA

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If you have a question about this talk, please contact Prof. Jim Kaufman .

Host: Helga Schneider (hs383@cam.ac.uk)

Professor Fionula Brennan

My research interests over the last 20 years or so have focussed on cytokine regulation in chronic inflammatory disease. My research studies indicated the importance of TNF as a potential therapeutic target in rheumatoid arthritis, which led to the first trials of anti-TNF antibodies in RA in man.

More recently I have studied how T cells in the synovial joint drive chronic inflammation. These studies indicate that these T cells resemble ‘by-stander’ activated T cells (not antigen-driven) and studies on a surrogate model for these RA synovial T cells have indicated the cell surface molecules important for contact-dependent activation of macrophages.

In the seminar today I will discuss very recent data on regulatory T cell function in this surrogate T cell model, and how this contributes to regulation of inflammation in chronic inflammatory diseases.

This talk is part of the Immunology in Pathology series.

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