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Remodeling of Mitochondria during Microbial Infection

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If you have a question about this talk, please contact Hannah Burns .

The rewiring of mitochondrial metabolism serves as an innate immune-type defense mechanism that restricts the growth of the human parasite Toxoplasma gondii. We recently reported a previously undescribed structure we term SPOT (structure positive for outer mitochondrial membrane (OMM) that emerges from the OMM during infection. We propose that Toxoplasma hijacks the formation of SPO Ts, a cellular response to OMM import stress, to counteract mitochondrial nutrient defense and promote its growth. Here, I discuss the fate and function of these peculiar structures.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

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McGrath Centre, St Catharine's College, Cambridge. Rainbow Seminar Room (SS03), Computer Laboratory Cambridge Museum of Technology, Cheddars Lane, Cambridge, CB5 8LD

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