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Mitochondria dynamics and metabolism regulate species-specific features of human brain development

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If you have a question about this talk, please contact Lisa Arnold .

The human brain, in particular the cerebral cortex, has undergone rapid expansion and increased complexity during recent evolution.

One striking feature of human corticogenesis is that it is highly protracted in time, from prenatal stages of neurogenesis (taking months instead of days in the mouse), to postnatal stages of neuronal maturation and circuit formation (taking years instead of weeks in the mouse). This prolonged development is thought to contribute in an important fashion to increased cortical circuit complexity and plasticity, but the underlying mechanisms remain poorly understood.

Here we will present data that indicate that species-specific mitochondria dynamics and metabolism contribute in an important fashion to control key fate transitions and set the tempo of human corticogenesis, with interesting implications for human brain evolution and diseases.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

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