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Unraveling the molecular evolution of betalain-producing enzymes to boost their industrial application

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If you have a question about this talk, please contact Kumari Billakurthi .

Betalains, the pigments restricted to some plants within the order Caryophyllales, have gained great interest in the last decades due to their properties as antioxidant, antitumoral and anti-inflammatory compounds but also due to their biosynthetic compounds pathway. Gene duplications within the lineage of the key enzyme L-DOPA-extradiol-dioxygenase (DODA) gave rise to enzymes with high dioxygenase activity, via neofunctionalization, involved in the production of betalains. Additionally, the convergent evolution of betalains has recently been confirmed by analyses of the evolution of the key enzyme DODA .

The reconstruction of these independent duplications within the different origins might help to understand the different molecular changes that were decisive in this gain of function, which may help to engineer these enzymes with higher efficiency in betalains production and could be of great interest to food, pharmaceutical and cosmetics industries.

This talk is part of the Plant Sciences Departmental Seminars series.

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Wellcome Genome Campus Conference Centre, Hinxton, Cambridge CB10 1RQ, United Kingdom Seminar Room A, Engineering, Institute for Manufacturing IfM Webinar & LT2, Computer Laboratory, William Gates Building.

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