Abstract

This hybrid seminar will be held in the meeting rooms, Level 4, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ , and online.

Free registration to attend this seminar in person at:

https://www.eventbrite.com/e/diabetes-no-more-lessons-from-the-direct-trial-and-beyond-prof-mike-lean-tickets-536094692657

Free registration to join this seminar online at:

https://mrc-epid.zoom.us/meeting/register/tJIrduqsrD0tH9FccP1uJ-Rzmk1bRy7JyCl8

After registering, you will receive a confirmation email containing information about joining the meeting.

About this talk Three RCT trials, conducted entirely in primary care using low-calorie formula diets for 8-12 weeks, have reported remissions for 40-60% of participants including South Asians, and 70-80% with weight loss >10kg, well maintained at 2 years. Hypertension and NAFLD , commonly accompanying T2D , normalized for ~30%. Remission was accompanied by normalization of ectopic fat in liver and pancreas, and insulin production capacity. With fewer serious adverse events, total medical care costs fell and cost-effectiveness analysis projected people to live longer, feel better and cost less. Remissions are strongly driven by weight loss, but new methods are needed to support longer maintenance.