Abstract

Precision medicine and personalised medicine are key priorities for health and social care delivery today. Precision medicine aims to tailor approaches for identifiable sub-groups within the general population, allowing more targeted delivery of interventions. Personalised medicine goes a step further, targeting each person as an individual. Often based upon genetic analyses, both have undergone extensive clinical investigations. This presentation will go over technology developments for what we see as the next step: continuous sensors that allow time varying medicine, reflecting individuals who vary on a day-by-day basis: and beyond this into closed loop approaches where sensing and actuation are combined to dynamically optimise interventions. I will go over this from a technology point of view, demonstrating technologies created at the University of Manchester for circadian rhythm sensing, and non-invasive bioelectronic approaches. The latter will focus on flexible electronics technologies for next generation wearables, from the electrodes to the electronics, to applications with closed loop non-invasive brain stimulation.