University of Cambridge > Talks.cam > MRC LMB Seminar Series > LMB Seminar: Power to the protein: analyse, signal and protect with bacterial superglues

  Browse A-Z

Log in

University Account External (via Google)

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹī¸ Information

LMB Seminar: Power to the protein: analyse, signal and protect with bacterial superglues

Download to your calendar using vCal

If you have a question about this talk, please contact Scientific Meetings Co-ordinator .

A special feature of the bacterium Streptococcus pyogenes enables spontaneous amide bond formation within its surface proteins. We re-engineered this system to generate an irreversible peptide-protein interaction (SpyTag/SpyCatcher). This reaction is genetically-encodable, specific in diverse biological environments, and occurs at a rate close to the diffusion limit. Latest advances include a toolbox of modules for rapidly controlling protein architectures and interaction switchable by temperature, pH or light. We have also developed another bacterial superglue called NeissLock for covalent reaction to endogenous human proteins via an anhydride. For targeting in the GI tract, we have been engineering plant-based proteins with extreme resilience to low pH and proteases. Applications of the technologies will be discussed for hydrogen-deuterium exchange, cell therapy and vaccination, including for emerging pandemic threats.

X/Twitter account – @HowarthSci

This talk is part of the MRC LMB Seminar Series series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

The obesity epidemic: Discussing the global health crisis Webinar & FW11, Computer Laboratory, William Gates Building. Mondays (unless otherwise stated), 13.05 – 14.00 in the Kenneth Craik Room ( Craik Marshall Building, Downing Site

Other talks

Wolfson Tool Factory Scattering Plenty: the people who made the modern countryside Online Causal Inference Seminar CSAR lecture: In a post-Ozempic world, have we cured obesity? Caribbean Trip and Cacti Optimal metric and approximation of free boundary minimal surfaces
 

Š 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity