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Genome editing of red cell precursors and Plasmodium falciparum to study host-parasite interactions in malaria

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If you have a question about this talk, please contact Anna Protasio .

Adhesion interactions between P. falciparum infected erythrocytes and human cells underlie the pathology of severe malaria. We are using CRISPR -Cas9 genome editing to identify the molecules involved in virulence-associated adhesion phenotypes such as rosetting, the binding of infected erythrocytes to uninfected ones to form clusters of cells that contribute to microvascular obstruction and malaria pathology. Unpublished data will be presented including editing of an erythroid precursor cell line to knockout candidate rosetting receptors, and reverse genetic studies of the parasite adhesion molecule PfEMP1 to identify key adhesion domains and make modifications such as epitope tags to facilitate future investigations of this diverse and multifunctional protein family

This talk is part of the Parasitology Seminars series.

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