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Chasing the ghost behind germination and starvation: the unidentified hormone ‘KL’

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KAI2 -Ligand (KL) is a putative plant hormone of unknown chemical identity. It acts through a receptor KAI2 /D14L, present throughout the green linage, to degrade repressor proteins (SMAXs), and impacts germination, nutrient sensing, and a wide range of developmental processes. The Paszkowski lab has shown that rice D14L is utterly essential for the plant to interact with arbuscular mycorrhizal fungi. I will discuss our attempts to elucidate how KL promotes mycorrhizal colonisation and integrates nutrient and light signalling. I have produced a suite of protein biosensors to monitor KL signalling as part of the ENSA collaboration, as we attempt to bring this knowledge into practical use to maintain the benefits of the symbiosis in the field under nonpermissive fertilisation. I take a drug discovery approach; screening small molecules for D14L agonism with an in vitro FRET assay, then assessing protein turnover in planta with a ‘degron’ sensor.

This talk is part of the Plant Sciences Departmental Seminars series.

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