Abstract

Nuclear envelope integrity in health and disease

Dr Anne Janssen

University of Cambridge, Department of Pharmacology

Biography

Anne studied Biotechnology at Wageningen University. After finishing her Masters degree she started her PhD in the lab of Lukas Kapitein (Utrecht University, the Netherlands) working on the generation of inducible tools to study protein aggregation and degradation by the autophagy pathway. During her PhD work she got interested in the nuclear envelope which is why she joined the lab of Delphine Larrieu in 2019 to work on nuclear envelope integrity and premature aging diseases. Initially at CIMR , the lab moved to the department of Pharmacology in 2022. Currently, Anne works on an independent project for which she got a Leverhulme Early Career Fellowship to discover new players in nuclear envelope integrity maintenance.

Dr Luke Pattison

A role for the proton-sensing GPCR , GPR65 in inflammatory joint pain

University of Cambridge, Department of Pharmacology

Biography

Luke studied Molecular and Cellular Biology at the University of Bath. During his undergraduate degree he undertook a placement at the Monash Institute of Pharmaceutical Sciences in Melbourne, Australia, where he studied the compartmentalised signalling of a G protein-coupled receptor (GPCR) implicated in inflammatory pain. Luke undertook his doctoral research in the Smith lab, submitting his thesis in 2021, which explored the contributions of proton-sensing GPC Rs to inflammatory pain. Luke is continuing in the Smith lab as a postdoctoral researcher working on the Advanced Discovery of Visceral Analgesics via Neuroimmune Targets and the Genetics of Extreme human phenotypes (ADVANTAGE) consortium as part of the MRC Advanced Pain Discovery Platform.

Venue: Level 2 Seminar Room

Zoom Link: https://cam-ac-uk.zoom.us/j/89184640892?pwd=VnZXbEU4bDdtbkt5MEV2NWt0RUJtUT09

Meeting ID: 891 8464 0892

Passcode: 620598