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Non-uniform regulation of epigenetic marks via metabolism in a developing tissue

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If you have a question about this talk, please contact Lisa Arnold .

Histone acetylation regulates gene expression, cell function, and cell fate. We studied the pattern of histone acetylation in an epithelial tissue, the Drosophila wing disc and find that H3K18ac, H4K8ac, and total lysine acetylation are elevated in the outer rim of the disc. This is due in part to high fatty acid β-oxidation (FABO) in the rim, and partly due to nuclear positioning. This affects gene expression. In sum, there is a physical mark of the outer rim of the wing and other epithelia in Drosophila.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

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