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Mechanism for Membrane Protein Insertion and Complex Assembly

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The human genome encodes approximately 5000 membrane proteins of varied sizes, shapes, and biophysical properties. To function properly, most of these proteins need to be inserted into the membrane in the correct orientation, folded into their three-dimensional structure, and assembled with partner proteins. How these membrane proteins are correctly made is not well understood. Using a biochemical approach to study factors involved in membrane protein biogenesis, I will discuss an emerging and unifying model for membrane protein insertion and the identification and characterization of assembly factors that facilitate complex formation.

This talk is part of the Biochemistry Seminar Series - External Speakers series.

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