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Isabelle Migeotte IRIBHM - Jacques E. Dumont Institut Interdisciplinaire en biologie humaine et moléculaire - Université Libre de Bruxelles, Brussels, BE 
Tuesday 15 October 2024, 14:30-15:30
Non-apical mitoses contribute to cell delamination during mouse gastrulation
- 👤 Speaker: Isabelle Migeotte IRIBHM - Jacques E. Dumont Institut Interdisciplinaire en biologie humaine et moléculaire - Université Libre de Bruxelles, Brussels, BE
- 📅 Date & Time: Tuesday 15 October 2024, 14:30 - 15:30
- 📍 Venue: online TUESDAY
Abstract
During the epithelial-mesenchymal transition driving mouse embryo gastrulation, cells divide more frequently at the primitive streak, and half of those divisions happen away from the apical pole. We challenged the molecular determinants of mitosis position in different regions of the epiblast through computational modeling and pharmacological treatments of embryos and stem cell-based epiblast spheroids. Disturbance of the actomyosin cytoskeleton or cell cycle dynamics elicits ectopic non-apical mitosis and shows that the streak region is characterized by local relaxation of the actomyosin cytoskeleton and less stringent regulation of cell division. These factors are essential for normal dynamics at the streak and favor cell delamination from the epiblast.
Join the Zoom with the link: https://cam-ac-uk.zoom.us/j/87503254733 Meeting ID: 875 0325 4733
Series This talk is part of the Morphogenesis Seminar Series series.
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