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A V HILL LECTURE Pain: Why does it exist, how does it work and how can we more effectively treat it?

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If you have a question about this talk, please contact Beverley Larner .

The sensation of pain is one which nearly everyone is familiar with, usually being considered an unpleasant experience. Wouldn’t a life without pain be better? Drawing on human genetics and the wider animal kingdom, we shall see that there are in fact benefits to pain, or rather nociception, the neural process encoding noxious stimuli. Pain is not however static. For example, following an accident, the injured part of the body becomes more sensitive, a phenomenon that usually resolves as the injury heals. Understanding the molecular processes by which pain functions and how the sensitivity in the system changes under different conditions is important for the development of novel therapeutics to treat the chronic pain, such as that associated with osteoarthritis, inflammatory bowel disease, endometriosis, and a wealth of other conditions. Looking to potential new therapeutic avenues, we will discuss what can be learned from studying human genetics and extremophile organisms, such as the naked mole-rat, as well what the future holds regard gene- and cell-based therapy.

This talk is part of the Cambridge Philosophical Society series.

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Seminar Room 9, Clinical SChools, Hills Road, CB2 0SP FUN Cambridge Rooms SG1 & SG2, Alison Richard Building, 7 West Road, Cambridge, CB3 9DT

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