Abstract

This Cambridge Immunology and Medicine Seminar will take place on Friday 8 November 2024, starting at 1:00pm, in the Ground Floor Lecture Theatre, Jeffrey Cheah Biomedical Centre (JCBC)

Speaker: Dr Marty Taylor, Assistant Professor of Pathology and Laboratory Medicine, Brown University

Bio: Marty Taylor is a clinician-scientist working to build a molecular understanding of the human LINE -1 transposon (L1) and leverage transposon biology into novel strategies for early diagnosis, prevention, and treatment of cancer and autoimmunity. His recent Nature paper (Nature. 2024 PMID : 38096902) revealed the first structures of the key L1 ORF2 reverse transcriptase, and provided key mechanistic insights into L1 polymerization and insertion, enabling rational drug development. In his new laboratory at Brown University, his team are dissecting LINE mechanism and pathophysiology, building a detailed molecular understanding of L1:host interactions and their consequences, and leveraging these insights into novel diagnostics and therapeutics.

Talk Title: “Structure and Mechanisms of LINE -1 retrotransposons: an Emerging Cancer Target”

Host: Paul Lehner, CITIID , Department of Medicine

Refreshments will be available following the Seminar.