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Simonetta Gribaldo, Intstitut Pasteur
Monday 10 March 2025, 11:00-12:00
LMB Seminar - One or two membranes? Investigating the transition between monoderm and diderm cell envelopes across the Tree of Bacteria - IN PERSON ONLY
- đ¤ Speaker: Simonetta Gribaldo, Intstitut Pasteur
- đ Date & Time: Monday 10 March 2025, 11:00 - 12:00
- đ Venue: In person in the Max Perutz Lecture Theatre (CB2 0QH)
Abstract
The cell envelope is one of the oldest and most fundamental biological structures, and a major target of antimicrobials. Bacteria can have radically different envelopes, containing either one (monoderm) or two (diderm) membranes, generally known as Gram-positives and Gram-negatives. How and why such dramatic transition occurred has remained a major open question in evolutionary biology. In my talk, I will present recent data where we addressed this issue by merging large-scale computational analyses with experimental evolution using a new bacterial model at the interface between diderms and monoderms. Our results challenge established paradigms and propose a hypothesis on how the monoderm/diderm transition might have occurred.
Series This talk is part of the MRC LMB Seminar Series series.
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