Abstract

Speaker: Dr Shota Hodono, Donders Center for Cognitive Neuroimaging, Nijmegen, Netherlands.

Title: Detectability and cortical depth dependence of stimulus-driven high-frequency BOLD oscillations in the human primary somatosensory and motor cortex.

Abstract: In this talk, I will present our work investigating the temporal specificity of Blood Oxygen Level Dependent (BOLD) based fMRI, in human primary somatosensory and motor cortex (https://doi.org/10.1162/imag_a_00427). Gradient recalled echo BOLD contrast allows inference of neuronal activity from associated hemodynamic changes. Consequently, the local vascular architecture influences both the sensitivity and specificity of BOLD fMRI. The spatial specificity has been well studied. However, the temporal aspects have been explored less. We studied the detectability of stimulus-driven high-frequency BOLD signal oscillations in M1 and S1 using cortical depth as a proxy for the vascular hierarchy. We observed that, at stimulation frequencies above 0.33 Hz, the relative contribution of larger draining veins near the pial surface was significantly attenuated. This suggests that, in addition to low spatial specificity, large draining veins may also exhibit reduced temporal specificity. In this method-focused seminar, I will also dive into the details of the experimental protocols, the rationale of the scan parameters, our distortion-matched T1-EPI anatomical imaging, and strategies used to analyze the data.

Bio: Shota enrolled the Biomedical Engineering PhD program at the New York University school of medicine in the Cloos group. After 1.5 years at NYU , he transferred together with his PhD supervisor to the University of Queensland in Australia. During his PhD, Shota focused on technological developments for UHF fMRI and investigated temporal specificity of fMRI using GRE -BOLD, diffusion fMRI, and DIANA . Currently, he is working as a postdoctoral fellow at the Donders Center for Cognitive Neuroimaging under the supervision of David Norris, focusing on technological developments for in-vivo transcranial ultrasound (TUS)-fMRI.

Venue: MRC CBU West Wing Seminar Room and Zoom https://us02web.zoom.us/j/82385113580?pwd=RmxIUmphQW9Ud1JBby9nTDQzR0NRdz09 (Meeting ID: 823 8511 3580; Passcode: 299077)