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Structural and molecular basis of DNA transfer by bacterial conjugative systems

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Bacterial conjugation is the unidirectional transport of genetic materials from a donor to a recipient cell. It plays crucial roles in bacterial evolution and adaptation. It is also the principal means by which antibiotic resistance genes spread among bacterial populations. It is mediated in the donor cell by three major complexes that work in concert: a DNA -processing machinery called the relaxosome, a double-membrane spanning transfer machinery termed type 4 secretion system (T4SS), and an extracellular appendage termed pilus. For this seminar, focus will be on the recent structures we have determined, notably that of the relaxosome.

This talk is part of the Biochemistry Seminar Series - External Speakers series.

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