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A telomeric tale: 2500 years of human betaherpesvirus evolution

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If you have a question about this talk, please contact Henry North .

Human betaherpesviruses 6A and 6B are double-stranded DNA viruses carried by large fractions of the human population and integrate into the human genome, leading to a wide range of clinical manifestations such as angina and pre-eclampsia. Despite only being discovered in the 1980s, these viruses are speculated to have a much longer history within the human population than modern data make clear. In this talk, I will present the first nine full and two partial ancient genomes of HHV -6A and 6B, dating as far back as the Italian Iron Age. We demonstrate that large fractions of current HHV -6 diversity were already well established in the human population by the 14th century CE, and likely much earlier.

This talk is part of the Zoology Departmental Seminar Series series.

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