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Molecular bases of Shigella virulence and host immune response

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  • UserProfessor Benoit Marteyn from Institute of Molecular and Cellular Biology (IBMC), University of Strasbourg
  • ClockThursday 06 November 2025, 14:00-15:00
  • HouseBiffen Lecture theatre and Zoom.

If you have a question about this talk, please contact Caroline Newnham .

Host – Kate Baker

Shigella are pathogenic enterobacteria responsible of bacillary dysentery or shigellosis. Shigella virulence relies on the expression of secretion systems (T3SS, T5SS ) and its ability to evolve in and adapt to changing microenvironments. The development of a pan-Shigella vaccine – which is still lacking – requires a better understanding of Shigella virulence strategies, adaptation to its host and, more importantly, the validation of a suitable animal model of shigellosis, to assess protection conferred by candidates.

I will present the most recent studies developed in my team, focusing on the importance of the pO2, its fine tuning during infection and subsequent modulation of Shigella secretion systems’ activity and immune response efficacy (mainly neutrophils). I will further develop the study of the interrelationship between shigellosis and vitamin C deficiency based on recent clinical studies and fundamental researches on new shigellosis animal models.

This talk is part of the Genetics Seminar series.

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