Abstract

Resolving the underlying mechanisms of complex neural functions and associated disorders remains a major challenge in neuroscience, largely due to the difficulty in mapping large-scale neural network dynamics with high temporal and spatial resolution. Interacting with the nervous system using a combination of modalities—electricity, light, and ultrasound—offers a promising approach to surpass conventional resolution limits. In this talk, I will introduce our recent work on developing soft neural interfaces that operate seamlessly in a multimodal fashion for both in vitro and in vivo applications. I will also briefly discuss our advances in medical-grade soft substrates and novel conformal encapsulation strategies for chronic neural implants, addressing critical challenges in the long-term stability and integration of neuroelectronic systems.