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Probing the dynamics of chronic disease using stable isotopes and mass spectrometry

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If you have a question about this talk, please contact Duncan Simpson .

Chronic disease is characterised by insidious or intermittent homeostatic dysregulation, leading to persistent disruption of normal organ function. Its course is often difficult to predict, in part because underlying causal networks or disease-critical pathways are difficult to probe on relevant time scales. One approach to this problem is to measure homeostatic dysregulation of critical pathways directly to uncover incipient change. This talk will highlight the use of macromolecular biosynthetic labelling with heavy water to probe normal and pathologically altered homeostasis. Methodological developments and challenges will be discussed, as well as applications in the study of autoimmune diseases.

This talk is part of the Physics of Medicine (PoM) Seminar Series series.

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Room SG1 of the Alison Richard Building, 7 West Road, CB39DT, Cambridge Senior Parlour, Gonville & Caius College CambPlants Hub

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