University of Cambridge > Talks.cam > Seminars on Quantitative Biology @ CRUK Cambridge Institute > Unexpected complex dynamics of cellular transcriptional response

  Browse A-Z

Log in

Googledetails Microsoftdetails

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹī¸ Information

Unexpected complex dynamics of cellular transcriptional response

Download to your calendar using vCal

If you have a question about this talk, please contact Florian Markowetz .

A major component of the response of cells to changing conditions is a shift of the transcriptome to a new state which may be more adequate for facing the new environment. The time dependence of this shift is of considerable interest and is often inferred from measurements of mRNA concentrations.

We formulate a refined model for the dynamics of pre-mRNA and mRNA concentrations and show that the temporal profiles of pre-mRNA are much more suitable than those of mRNA for reconstruction of the transcript production profiles. By monitoring time-dependent changes of pre-mRNA abundance in MCF10A cells stimulated by EGF , we show that in general, production profiles exhibit different kinds of interesting and unexpected forms. In order to increase expression of specific genes to some high desired level in a short time, cells use a strategy of production overshoot for a relatively brief interval.

A genome wide view shows while these production profiles are closely reflected by the time dependence of the pre-mRNA, the corresponding mRNA profiles (which also exhibit unexpected complexity) are often uncorrelated with transcript production.

Hosted by Nitzan Rosenfeld.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Potter Room in-person (also online) - Details to be sent by email Hybrid: JDB Teaching Room, Engineering Department or Zoom: https://cam-ac-uk.zoom.us/meeting/register/tZ0tfuCvrDgjG9WNY52TL0qsu7PqO484Pad5 Unilever Lecture Theatre

Other talks

Title to be confirmed C2D3 Computational Biology Annual Symposium 2026 Title to be confirmed Title to be confirmed Royal Papworth Hospital and Acute Medicine Discovery Investigations: Science, Empire and the Making of the British South Atlantic
 

Š 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity