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Wednesday 12 November 2025, 15:00-16:00
Quantity and Quality: Mechanisms of Mitochondrial DNA Copy Number and Integrity Control in Saccharomyces cerevisiae
- đ¤ Speaker: Professor Dr Christof Osman, Biocenter of the LMU, Germany
- đ Date & Time: Wednesday 12 November 2025, 15:00 - 16:00
- đ Venue: MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY
Abstract
Mitochondrial DNA (mtDNA) maintenance relies on mechanisms that control both the amount and the integrity of the genome. We identify factors and principles that underlie mtDNA homeostasis and investigate how they contribute to copy number regulation and quality control. Using S. cerevisiae as a model, we apply genetic approaches and quantitative imaging to dissect these processes across different levels of organization, from molecular interactions to cellular outcomes. Recent work has revealed pathways that determine mtDNA abundance, as well as mechanisms that promote the preferential maintenance of functional genomes over defective ones. Together, these findings provide a framework for understanding how eukaryotic cells maintain an adequate and functional mitochondrial genome population.
Series This talk is part of the MRC Mitochondrial Biology Unit Seminars series.
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