Abstract

This week we will discuss and debate a very recent paper by Li and colleagues (2025).

Abstract: “Our brain is remarkably limited in how many items it can hold simultaneously, but it can also represent unbounded novel items through generalization. How the brain rationally uses limited resources in working memory (WM) remains unexplored. We investigated mechanisms of WM resource allocation using calcium imaging and electrophysiological recording in the prefrontal cortex of monkeys performing sequence WM (SWM) tasks. We found that changes in the neural representation of SWM , including geometry, generalizable and separate rank subspaces, reflected WM load. SWM resources, represented by neurons’ signal strength and spatial tuning projected onto each rank subspace, were shared flexibly between ranks. Crucially, the prefrontal cortex dynamically utilized shared tuning neurons to ensure generalization, while engaging disjoint and spatially shifted neurons to minimize interference, thus achieving a trade-off between behavioral and neural costs within capacity. The allocated resources can predict monkeys’ behavior. Thus, the geometry of compositionality underlies the flexible use of limited resources in SWM ” (Li et al., 2025).

Reference: Li, S., Chen, J., Zhang, C., Tang, S., Xie, Y., & Wang, L. (2025). Flexible Use of Limited Resources for Sequence Working Memory in Macaque Prefrontal Cortex. Nature Communications, 16(1), 10386. https://doi.org/10.1038/s41467-025-65380-0