University of Cambridge > Talks.cam > Keita Tamura Lab @ PDN > Neural correlates of probabilistic decision making in S1 during virtual reality navigation

Neural correlates of probabilistic decision making in S1 during virtual reality navigation

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Abstract

Utilising tactile VR to harness ethologically relevant whisker-guided navigation behaviour in mice reveals striking decision related signals in the early cortical hierarchy. Large-scale Neuropixel recordings and optical perturbation experiments show these signals in S2 are fed back into S1 to fundamentally change how sensory information is processed during salient decision making.

References

Armstrong, A.G. & Vlasov, Y. Neural correlates of perceptual decision making in primary somatosensory cortex. BioRxiv https://doi.org/10.1101/2025.03.29.646003

Armstrong, A.G. & Vlasov, Y. (2026) Probabilistic perceptual decision-making during whisker-guided navigation causally depends on a single cortical barrel column. Journal of Neuroscience https://doi.org/10.1523/JNEUROSCI.0930-25.2026

Akritas, M, Armstrong, A.G. et al. (2024) Nonlinear sensitivity to acoustic context is a stable feature of neuronal responses to complex sounds in auditory cortex of awake mice. eLife 13:RP98415. https://doi.org/10.7554/eLife.98415.1

Armstrong, A.G. et al. (2022) Compression and amplification algorithms in hearing aids impair the selectivity of neural responses to speech. Nature Biomedical Engineering 6:717–73. https://doi.org/10.1038/s41551-021-00707-y

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