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Mapping Synthetic Genetic Interaction Networks by High-throughput RNAi

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If you have a question about this talk, please contact Katrien Van Look .

To uncover the causal relationship between phenotypes and the underlying genotypes is a long-standing challenge in biology. Identification of quantitative trait loci in crosses of yeast strains shows evidence that many heritable traits have interacting loci, highlighting the role of genetic interactions in the pathogenesis of complex diseases. Synthetic genetic interaction analysis can be used to study the functional relationships between genes on a genome-wide scale, yielding genetic interaction profiles that sensitively reflect their molecular functions. We have developed a robust and scalable framework to quantitatively measure genetic interaction profiles in Drosophila cells, using multiparametric cellular imaging and pairwise RNA interference. Mathematical modelling of the double perturbations allow to reconstruct known molecular pathways. A second topic of the talk will be the analysis of signaling pathways using high-dimensional phenotyping and large-scale perturbation studies.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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