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DNA replication: for better or for worse

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If you have a question about this talk, please contact Duncan Simpson .

When a cell replicates its DNA , each base must be copied once and only once per cell cycle. A failure to complete replication normally can lead to cell death, or worse. In this talk, I will discuss how ideas from statistical physics can help understand how replication is organized and controlled, including biological mechanisms and effects of damage that interrupts the progress of normal replication. The overall theme is that passive stochastic control and physical effects such as diffusion are more relevant than had been believed until recently.

This talk is part of the Physics of Medicine (PoM) Seminar Series series.

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