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"Structural Changes in the brain with Alzheimer's disease."

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If you have a question about this talk, please contact Shannon Tinley-Browne .

One of the cardinal features of Alzheimerâ•˙s disease (AD) is amyloidosis , characterized by an over abundance of beta amyloid (Abeta) in brain tissue, an increase in the ratio of Abeta42 to Abeta40, and the deposition of Abeta in senile plaques in the brain . It is widely believed that this amyloidosis is an early event in a cascade of neurodegenerative events that ultimately results in the loss of synapses and neurons and ultimately in the cognitive decline associated with the disease. In this talk I will focus on the structural changes that take place in the brains of Alzheimerâ•˙s patients and in transgenic mice that model amyloidosis of the type associated with AD. Quantitative measures of the number and size of neuron and synapse observed during the different stages of amyloidosis of the Alzheimer type will be presented and discussed in terms of potential mechanisms involved in the development of the disease.

This talk is part of the BRC Seminar Series series.

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