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Thursday 31 March 2011, 16:15-18:00
The Cellular Basis for the Cancer-Related Phenomena of Immune Suppression and Cachexia
- 👤 Speaker: Doug Fearon
- 📅 Date & Time: Thursday 31 March 2011, 16:15 - 18:00
- 📍 Venue: Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol
Abstract
Although cancers elicit immune responses, they occur. This paradox must be understood to improve cancer immunotherapy. “Stromal” cells (all non-cancer cells in the tumor) prevent cancer-specific immune responses from controlling tumor growth, but the diversity of this population has hindered identification of the relevant cell type. We developed a mouse model that enables the conditional ablation of a stromal cell type that was recognized 20 years ago by its expression of the membrane protein, “fibroblast activation protein-alpha”, or FAP . Ablating FAP stromal cells causes immune-mediated necrosis of established tumors. FAP cells reside also in skeletal muscle where their depletion leads to a wasting condition resembling cancer cachexia. Thus, the redistribution of the FAP + cell from normal tissues to tumors may link the cancer-related phenomena of immune suppression and cachexia.
Series This talk is part of the MRC LMB Seminar Series series.
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