University of Cambridge > Talks.cam > Seminars on Quantitative Biology @ CRUK Cambridge Institute > Adult stem cell fate: a laboratory for statistical physics

  Browse A-Z

Log in

Googledetails Microsoftdetails

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹ️ Information

Adult stem cell fate: a laboratory for statistical physics

Download to your calendar using vCal

If you have a question about this talk, please contact Florian Markowetz .

In adult, tissues are maintained and repaired by stem cells, which divide and differentiate to generate more specialized progeny. The mechanisms that control the balance between proliferation and differentiation promise fundamental insights into the origin and design of multi-cellular organisms. However, stem cells are usually difficult to distinguish from their more differentiated progeny, and resolving these mechanisms has proved challenging. Combining the results of inducible genetic labeling studies from a range of tissue types with concepts from population dynamics and statistical physics, we show how scaling behaviour of clone size distributions reveals signatures of stochastic stem cell fate. As well as providing insight into the molecular regulatory mechanisms controlling the maintenance, repair and regeneration of adult tissues, these results provide a platform to explore pathways of dysregulation and tumorigenesis.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

FAMES, Room 8/9 Lecture Theatre 0, University of Cambridge Department of Engineering, Trumpington Street, Cambridge CB2 1PZ

Other talks

The Neurophenomenology of Surrender: Agency, Renewal, and Social Engagement in Speaking in Tongues Title TBC The Imagined Conflict: On Science and God  Life, death, and the discovery of PDAR: the Pol II Degradation-dependent Apoptotic Response  Title to be confirmed Harnessing Radical Reactivity for Molecular Innovation
 

© 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity