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"Myeloproliferative neoplasms – JAK/STAT signalling and stem cell subversion"

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  • UserProf Tony Green, University of Cambridge Department of Haematology
  • ClockTuesday 21 February 2012, 12:00-13:00
  • HouseCRI Lecture Theatre.

If you have a question about this talk, please contact Mala Jayasundera .

The JAK /STAT pathway plays a key role in stem cell biology and is implicated in many human malignancies. A single acquired gain-of-function V617F mutation in JAK2 is present in most patients with a myeloproliferative neoplasm (MPN), a spectrum of clonal haematological malignancies which arise in the haematopoietic stem cell compartment. These disorders are experimentally tractable, permit clonal analysis and provide a window on the earliest stages of tumorigenesis. The Green lab is focussing on the pathogenesis of the MPNs and particularly on the molecular and cellular consequences of aberrant JAK /STAT signalling. Recent highlights of general relevance for stem cell and cancer biology include unexpected insights into chromatin biology, clonal evolution and haematopoietic stem cell function.

This talk is part of the Cambridge Oncology Seminar Series series.

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