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Differential metabolic profile in first episode psychosis supports the glutamate theory for schizophrenia

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If you have a question about this talk, please contact Lorraine Coulson .

Some metabolic dysregulations are inherent to psychotic disorders. Metabolomics – a new technique that analyses the complete collection of metabolites produced by an organism – has led to the discovery of metabolites in post-mortem brains and peripheral blood in schizophrenia. We were interested in the identification of metabolic compounds in peripheral blood that allow the identification of individuals with a first episode of psychosis (FEP), amongst their first-degree relatives and healthy unrelated controls. The identification of metabolic endophenotypes in psychotic disorders may support diagnosis and treatment and increase the currently limited understanding of the pathophysiology of these disorders.

This talk is part of the Behavioural and Clinical Neuroscience Seminars series.

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