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FGFR2-associated gene expression networks in breast cancer

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Fibroblast Growth Factor Receptor 2 (FGFR2) is a low-risk breast cancer susceptibility gene. Its role in the etiology of breast cancer is unknown. We have used gene expression microarrays to profile the expression changes downstream of FGFR2 signalling in MCF7 cells. Our current analysis uses the ARAC Ne and MRA algorithms (Carro et al., Nature, 2010) to identify a network of transcription factors putatively regulating the FGFR2 -associated expression response. I will present the results of this and previous analyses, and discuss the future direction of our work.

This talk is part of the CRI joint computational biology meeting series.

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