Abstract

This is advance notice of this seminar. Dr Califano’s lab have been leaders in the development of biochemically validated genome-wide maps of transcriptional and post-transcriptional interaction in several human cell contexts, including different cancer types and normal and tumour-related stem cells. The Califano lab integrates the development of analytical methodologies with high-throughput experimental assays for data generation and biological/biochemical validation. In particular, the lab have developed the “master regulator” concept in human tumours and the “bottleneck” hypothesis of master regulator function in glioma. Recent publications include:

1. Califano A, Butte AJ, Friend S, Ideker T, Schadt E. Leveraging models of cell regulation and GWAS data in integrative network-based association studies. Nat Genet. 2012 Jul 27;44(8):841-7
2. Sumazin P, Yang XR, Chiu HS, Chung WJ, Iyer A, Llobet-Navas D, et al. An Extensive MicroRNA-Mediated Network of RNA -RNA Interactions Regulates Established Oncogenic Pathways in Glioblastoma. Cell. 2011;147(2):370-81.
3. Carro MS, Lim WK, Alvarez MJ, Bollo RJ, Zhao X, Snyder EY, Sulman EP, Anne SL, Doetsch F, Colman H, Lasorella A, Aldape K, Califano A, Iavarone A. The transcriptional network for mesenchymal transformation of brain tumours, Nature. 2010 Jan 21;463(7279):318-25. PMID : 20032975

Dr Califano is a clear speaker, and his talks are generally accessible to those who are not expert in the statistical and computational aspects of this field.