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Dr Clive Bate, Pathology & Infectious Diseases, The Royal Veterinary College
Wednesday 15 May 2013, 16:15-17:15
Molecular mechanisms of synapse degeneration in prion and Alzheimer's disease
- đ¤ Speaker: Dr Clive Bate, Pathology & Infectious Diseases, The Royal Veterinary College
- đ Date & Time: Wednesday 15 May 2013, 16:15 - 17:15
- đ Venue: Lecture Theatre 1, Department of Veterinary Medicine
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Suzy Blows
Abstract
Synapse degeneration is the key event leading to memory failure in Alzheimer’s and prion diseases. Prions and amyloid-beta42 (thought to be the major neurotoxin in Alzheimer’s disease) trigger synapse damage in cultured neurons. In this talk I will discuss the molecular mechanisms of synapse damage in response amyloid-beta42 and prions including experimental data implicating the role of specific receptors, lipid rafts and signalling cascades. I will then discuss possible intervention strategies based on the manipulation of these molecular pathways.
Series This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.
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