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Can structural studies of intact viruses really be useful in the search for better vaccines and antivirals?

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I will focus on picornaviruses, small well-studied viruses responsible for a range of human and animal dieases (from polio to the common cold), against which we have a smattering of useful vaccines and very little in the way of small molecule drugs. I will try to convince you that the increasing facility of structure analysis of such viruses makes it worth attempting to make better vaccines and new anti-virals by reference to structural information, illustrating this by our work especially on foot-and-mouth disease virus, which is responsible for a terrible disease in livestock, and the on the quite different viruses responsible for hand-foot-and-mouth disease in humans, currently endemic in South Asia. Attempting such a rational approach exposes the limits of our fundamental knowledge of how these viruses work, and how the immune system controls viral infections, but I will try to show that it can also throw new light on these fundamental questions.

This talk is part of the MRC LMB Seminar Series series.

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