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Insights in the metabolic control of T cell migration and function: implications for immune inflammation in metabolic diseases

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If you have a question about this talk, please contact David Williamson .

Metabolic diseases, including atherosclerosis, obesity and diabetes, and arthritis are a leading cause of morbidity. Low-grade T cell-mediated inflammation is associated with these conditions and contributes to their pathogenesis and progression. Our current studies indicate that interfering with metabolic pathways (i.e., lipid, glucose and oxidative metabolism) alters T cell trafficking and function in vitro and in vivo. The major hypothesis we are investigating is that metabolic alterations lead to aberrant T cell migration patterns, which favour the establishment of chronic inflammation. We are exploring the mechanisms of metabolic control of T cell migration in physiology and under metabolic stress. We are also investigating the effect of drugs that correct altered metabolism (e.g., the antidiabetic drug metformin) on T cell trafficking and inflammation in murine models of obesity. These studies will provide insights into the role of energy balance on physiologic T cell trafficking and the effect of altering metabolism on the development of T cell-mediated inflammation.

This talk is part of the BRC Seminar Series series.

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