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Single molecule approaches for studying gene expression in intact mammalian tissues.

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If you have a question about this talk, please contact Florian Markowetz .

Mammalian tissues are composed of heterogeneous cells, interacting in highly structured microenvironments to achieve physiologic goals. Understanding tissue complexity requires developing quantitative tools for examining single cells within the natural tissue microenvironment. Our lab is developing approaches based on single molecule fluorescence in-situ hybridization that enable reconstructing all phases of gene expression, from chromatin states, through transcription rates to mRNA degradation while preserving the intact tissue structure. I will describe applications of this approach for studying stem cell identity in intestinal crypts as well as single cell heterogeneity in the mammalian liver.

Hosted by Nitzan Rosenfeld.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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