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Monday 02 September 2013, 12:00-13:00
Molecular imaging of tumor progression at the tumor/stromal boundary
- đ¤ Speaker: Patricia Keely, Associate Professor and Co-PI LOCI, Madison-Wisconsin đ Website
- đ Date & Time: Monday 02 September 2013, 12:00 - 13:00
- đ Venue: CRUK Cambridge Institute Lecture Theatre
Abstract
Appropriate cellular interactions with the extracellular matrix (ECM) help to establish normal cellular architecture and differentiation. During oncogenic transformation, these normal interactions with the ECM are profoundly altered, resulting in cells that lose their polarization and differentiation, lose anchorage dependent growth control, and acquire a migratory, invasive phenotype. Our lab is interested in understanding, at a molecular level, how cellular interactions with the ECM determine differentiation and epithelial polarization, and how these interactions are altered during carcinogenesis to result in invasive, metastatic carcinoma.
Series This talk is part of the Cambridge Advanced Imaging Seminars series.
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