Abstract

Preclinical and Clinical Animal Models in Translational Orthopaedic Research Matthew J. Allen, Vet. M.B., Ph.D.

Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH

The use of animals in research remains controversial. While efforts should always be made to replace animal use through the use of in-vitro alternatives such as cell culture or computer simulation, there remains a clear need for in-vivo studies to better define disease mechanisms and evaluate new therapies. In this presentation, I will review our experience with the use of preclinical animal models in musculoskeletal research, with a particular emphasis on orthopedic oncology, spine surgery and total joint replacement. I will also discuss the tremendous opportunities that exist in using clinical cases seen in the veterinary hospital as a natural bridge between the research laboratory and eventual clinical deployment of new medical and surgical treatment options in both humans and animals.