University of Cambridge > Talks.cam > Computer Modelling in Biology > Ligand detection and discrimination by spatial relocalisation: the complexities of T cell activation

  Browse A-Z

Log in

Googledetails Microsoftdetails

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹ️ Information

Ligand detection and discrimination by spatial relocalisation: the complexities of T cell activation

Download to your calendar using vCal

If you have a question about this talk, please contact Matthew Levin .

We analyse a theory of ligand triggering based on receptor relocation to regions of low phosphatase activity. The application is cell:cell communication and receptors where there is no known conformation change, but possessing short ectodomains. Through spatial segregation of long and short bonds/molecules in the cell:cell interface, large phosphatases can be excluded from regions of close contact. In these regions small receptors get trapped by binding to their ligands. We examine the sensitivity and specificity of such as system using a spatial lattice model and molecule diffusion and the requirements for it to have efficient detection characteristics.

This talk is part of the Computer Modelling in Biology series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

cu palestine society Webinar & LT2, Computer Laboratory, William Gates Building. Talk on the invention of the chronograph

Other talks

Sheref Mansy, topic TBA What’s my reproduction number? Life history strategies: an interdisciplinary perspective In conversation: Louis Herns Marcelin and Ola Osman on legacies of enslavement and contemporary violence in Liberia and Haiti How Much Does Homology Really Know? Machine Learning for Spectral Geometry and Vice Versa Title TBC
 

© 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity