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How dynein and its co-factors at the kinetochore ensure chromosome segregation fidelity.

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If you have a question about this talk, please contact Caroline Newnham .

Host: Viji Draviam

Accurate chromosome segregation during cell division requires attachments between spindle microtubules and the kinetochore, a multi-protein assembly that forms on each sister chromatid. The kinetochore also harbors the spindle assembly checkpoint, a signaling network crucial for chromosome segregation fidelity that detects errors in kinetochore-microtubule attachments. The Rod-Zw10-Zwilch complex (RZZ) and the coiled-coil protein Spindly, kinetochore-localized regulators of the motor cytoplasmic dynein, have essential roles in both spindle assembly checkpoint signaling and kinetochore-microtubule attachment, but the molecular underpinnings remain poorly understood. We have characterized engineered point mutations in RZZ subunits and Spindly using the nematode C. elegans and human cultured cells, which has allowed us to assign specific functions to individual RZZ subunits and has uncovered an important role for a posttranslational lipid modification in kinetochore assembly.

This talk is part of the Genetics Seminar series.

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