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Directed Growth of CNS Tissue on Engineered and Active Surfaces for Neural Device Application

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If you have a question about this talk, please contact Anna Walczyk .

Nanopatterning can be a strategy to improve biocompatibility of neural devices to modulate neural cells and reduce astrogliosis. Two different microelectrode materials, poly (methyl methacrylate), PMMA and sapphire are studied from the perspective of understanding cell-material interaction; in the former case to avoid astrocyte reactivity and in the latter case to promote neuronal cell attachment. The nanopatterning in these materials were achieved using nanoimprint lithography or hot embossing for PMMA and via photolithography, reactive sputtering and metal lift off for the case of sapphire with deposited iridium oxide thin film. Results from our investigation confirm that certain nanotopograhy features can be effective in these materials to improve their functionality. Cell-material interactions and biocompatibility of these materials are also addressed using controlled experiments and statistical results.

This talk is part of the Bioengineering Seminar Series series.

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